Which radiopharmaceutical is utilized for evaluating space-occupying lesions?

• A. Tc tetrofosmin
• B. Tc succimer (DMSA)
• C. Tc exametazime (HMPAO)
• D. Tc pertechnetate

Answer: (B)

The selection of Tc succimer (DMSA) as the appropriate radiopharmaceutical for evaluating space-occupying lesions is based on its specific imaging capabilities. DMSA is a radiolabeled compound that is primarily used for renal imaging, particularly to assess renal scarring and cortical abnormalities. It demonstrates a high affinity for the renal cortex, making it well-suited for identifying lesions in that region.

When considering space-occupying lesions, especially in the kidneys, DMSA provides detailed information about the cortical structure and function, helping to distinguish between healthy and abnormal tissue. In nuclear medicine imaging, the compound contributes to the assessment of morphology and can identify renal masses, thereby assisting in the clinical evaluation of potential tumors or other pathologies.

The other options, while they have their own specific applications, do not have the same targeted sensitivity for space-occupying lesions as Tc succimer. For instance, Tc tetrofosmin is primarily used for myocardial perfusion imaging, and Tc exametazime (HMPAO) is often used for brain perfusion studies rather than for identifying lesions. Tc pertechnetate is generally used for thyroid imaging and other organ studies but does not provide the detailed assessment required for evaluating lesions' structural