Which organs demonstrate normal biodistribution for Tc tetrofosmin?

• A. Heart, liver, kidney
• B. Thyroid, lungs, spleen
• C. Pancreas, breast, bladder
• D. Brain, skin, intestine

Answer: (A)

Tc tetrofosmin is a radiopharmaceutical used primarily in myocardial perfusion imaging. It is a lipophilic complex that shows a particular affinity for myocardial tissue, allowing for effective visualization of cardiac blood flow. The normal biodistribution of Tc tetrofosmin includes significant uptake in organs that have high blood flow, which explains why the heart, liver, and kidneys are prominently featured.

The heart receives a direct supply of blood and allows for the assessment of coronary artery function and heart viability. The liver and kidneys, while not the primary focus in cardiac imaging, are involved in the clearance and metabolism of various compounds, including radiopharmaceuticals, which is why they also show normal biodistribution for Tc tetrofosmin.

The other options consist of organs that do not demonstrate significant uptake of Tc tetrofosmin, as their physiology and blood flow characteristics differ from those of the heart, liver, and kidneys, leading to a different biodistribution profile for this radiopharmaceutical.