Which method is used to produce Tc-99m?

• A. Cyclotron
• B. Generator
• C. Reactor
• D. Electrolysis

Answer: (B)

The production of technetium-99m (Tc-99m) primarily occurs through a method known as a generator. Specifically, this involves the use of a molybdenum-99 (Mo-99) generator, where Mo-99 decays to produce Tc-99m. This process is advantageous as it allows for the convenient and periodic extraction of Tc-99m, which is essential in various medical imaging applications.

In a generator system, Mo-99, which has a suitable half-life and produces Tc-99m with a relatively short half-life, is immobilized in a column. As Mo-99 decays and produces Tc-99m, this can be eluted periodically, providing a steady supply of the radioisotope for use in diagnostic procedures without the need for elaborate equipment or long production times.

Utilizing a generator is particularly effective because it allows healthcare facilities to produce Tc-99m on-site as needed, thus ensuring freshness and availability for imaging purposes. This method also reduces reliance on external sources for supply, making it a key choice in nuclear medicine.