What type of scans are conducted with Tc exametazime (HMPAO)?

• A. Bone scans
• B. Brain perfusion scans
• C. Liver scans
• D. Kidney function tests

Answer: (B)

Tc exametazime, also known as HMPAO (hexamethylpropyleneamine oxime), is specifically used for brain perfusion imaging. This radiopharmaceutical is designed to assess cerebral blood flow, making it particularly valuable in the evaluation of various neurological conditions, such as stroke, dementia, and other brain disorders. When administered, Tc exametazime crosses the blood-brain barrier and becomes trapped in the brain tissue, allowing for visualization of cerebral perfusion and activity.

In contrast, bone scans typically utilize different radiopharmaceuticals, such as Tc methylene diphosphonate (MDP), which binds to areas of increased bone metabolism. Liver scans often involve agents that preferentially localize in hepatic tissue, while kidney function tests may utilize radiopharmaceuticals like Tc MAG3 or DMSA, which are specifically designed for renal imaging. Therefore, the application of Tc exametazime is distinctly focused on brain perfusion scans, underscoring its role in neuroimaging.