What is the normal biodistribution of Tc bicisate (ECD)?

• A. Brain, lungs, heart, liver
• B. Brain, kidneys, bladder, liver
• C. Intestines, kidneys, liver, stomach
• D. Heart, brain, bones, bladder

Answer: (B)

The normal biodistribution of Tc bicisate (ECD), a radiopharmaceutical used in brain imaging, primarily targets the brain. After administration, Tc bicisate is preferentially taken up by the brain tissue, allowing for effective visualization of cerebral perfusion. In addition to the brain, Tc bicisate is also excreted by the kidneys, leading to activity in the kidneys and subsequently in the bladder as urine collects. There is also a lesser distribution in the liver, which is typical for many radiopharmaceuticals due to hepatic metabolism and clearance processes.

This specific biodistribution pattern makes Tc bicisate particularly useful for assessing cerebral blood flow and evaluating conditions like stroke or other neurological conditions. The focus on the brain, kidneys, bladder, and liver accurately reflects its normal physiological distribution, supporting varied diagnostic applications.