What is the localization mechanism for Tc Sodium Pertechnetate during a Meckel's scan?

• A. Filtration
• B. Secretion
• C. Active transport
• D. Passive diffusion

Answer: (B)

The localization mechanism for Tc Sodium Pertechnetate during a Meckel's scan involves secretion. In this context, Tc-99m pertechnetate is utilized primarily because it mimics the behavior of certain bodily substances, particularly in the gastrointestinal tract. It is secreted by gastric mucosal cells into the stomach and intestines, which allows it to accumulate in specific tissues, such as those associated with Meckel's diverticulum.

Meckel's diverticulum is known to contain gastric mucosa that secretes gastric acid and, consequently, can secrete radiopharmaceuticals like Tc-99m pertechnetate, leading to its localization in that area. The capacity of the technetium compound to reflect the biological activity of secretion from these cells is critical for the accurate imaging and diagnosis of Meckel's diverticulum and other conditions.

This process highlights the importance of the chemical properties of technetium in mimicking physiological processes, which enhances the effectiveness of the scan in localizing the diverticulum or associated gastric tissue.