What is one contributing factor to the biodistribution of filtered Tc Sulfur Colloid?

• A. Particle size
• B. Temperature
• C. Molecular weight
• D. pH levels

Answer: (A)

The biodistribution of filtered Tc Sulfur Colloid is significantly influenced by particle size, as it directly affects the uptake and accumulation of the radiopharmaceutical in various tissues. Smaller particles tend to circulate in the bloodstream for extended periods and are more likely to be taken up by the reticuloendothelial system (RES), particularly in the liver and spleen. In contrast, larger particles may be trapped by the lungs or other tissues, leading to different biodistribution patterns.

Additionally, the filtration process used to prepare Tc Sulfur Colloid aims to achieve a specific particle size distribution, enhancing its efficacy for imaging purposes. Therefore, understanding how particle size influences biodistribution is crucial for optimizing the use of Tc Sulfur Colloid in diagnostic imaging.