What diagnostic imaging method utilizes both Tc sestamibi and Tc tetrofosmin?

• A. CT Angiography
• B. Myocardial perfusion imaging
• C. Bone scintigraphy
• D. Positron emission tomography (PET)

Answer: (B)

Myocardial perfusion imaging is a diagnostic technique that assesses blood flow to the heart muscle, particularly during rest and stress conditions. Tc sestamibi and Tc tetrofosmin are both radiopharmaceuticals used in this procedure. These agents are injected into the bloodstream and taken up by myocardial cells, allowing for visualization of perfusion through gamma cameras.

The utilization of these tracers specifically targets the evaluation of myocardial blood flow, making them integral to identifying conditions such as coronary artery disease, where areas of reduced perfusion can indicate ischemia or infarction. Their properties as lipophilic cationic compounds enable them to accumulate in healthy myocardial tissue, leading to effective imaging during stress tests, thereby helping to stratify cardiac risk and guide further management.

Other options, such as CT angiography, bone scintigraphy, and positron emission tomography, operate with different methodologies and tracers that do not align with the specific function of assessing myocardial perfusion using Tc sestamibi and Tc tetrofosmin.