In Tc RBCs biodistribution, which components are commonly identified?

• A. Tumor and fat
• B. Blood and soft tissue
• C. Heart and lungs
• D. Blood, heart, liver, spleen

Answer: (D)

The biodistribution of technetium-labeled red blood cells (Tc RBCs) is characterized primarily by their localization in various components of the circulatory and reticuloendothelial systems. The correct identification of blood, heart, liver, and spleen in this context reflects the physiological behavior of red blood cells within the body.

Red blood cells circulate in the bloodstream, hence the identification of blood as a significant component is expected. The heart serves as the pump that propels these cells through the vascular system, making it another key area of localization.

Moreover, the liver and spleen play critical roles in the recycling and filtration of red blood cells. The spleen is involved in the removal of old or damaged red blood cells, while the liver can also engage in various metabolic processes associated with blood cells. Thus, the accumulation of Tc RBCs in these organs is indicative of their normal physiological functions and the dynamics involved in the life cycle of red blood cells.

In summary, the identification of blood, heart, liver, and spleen in the biodistribution of Tc RBCs highlights important aspects of their physiological distribution and function in the body, making this answer the most accurate choice.